| Diagnosis of orthopaedic prosthesis infections with radionuclide techniques; clinical application of various imaging methods | ||
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In order to make this publication easier to read, exemplary data from some previous studies have been collected into Table 2. The selection of these examples is purely subjective and represents studies including the required documentation for this kind of tabulation and a series including hip and knee prosthesis infections, often among other orthopaedic infections. Because of varying aspects, including but not limited to the study methodology and documentation, no definite conclusions should be drawn based on this simplified table alone. However, particular attention should be paid to the variable follow-up periods of the patients in the reference methods column.
Table 2. Examples of studies utilising nuclear medicine procedures in the diagnosis of orthopaedic infections.
| Method | Publication | n prostheses | n patients | Sensitivity | Specificity | Reference method (follow-up time) |
|---|---|---|---|---|---|---|
| 67Ga/bone | Merkel et al. 1986 | hip 71, knee 14, other | 130 | 66 | 81 | Operative and clinical (2 years) |
| 99mTc-nanocolloid | Flivik et al. 1993 | hip 14, knee 7 | 21 | 100 | 82 | Operative and clinical (not specified) |
| 111In-HIG | Nijhof et al. 1997 | hip 85, knee 17 | 100 | 100 | 80 in hip, 50 in knee | Operative and clinical (6 months) |
| 18F-FDG-PET | Zhuang et al. 2001 | hip 38, knee 36 | 62 | 90 | 81 | Operative and clinical (1 year) |
| 111In-leukocyte/bone | Johnson et al. 1988 | hip 21, knee 2 | 28 | 88 | 95 | Operative only |
| 111In-leukocyte/marrow | Palestro et al. 1990 | hip 92 | 72 | 100 | 97 | Operative and clinical (6 months) |
| 111In-leukocyte/marrow | Palestro et al. 1991 | knee 41 | 28 | 86 | 100 | Operative and clinical (6 months) |
| 99mTc-leukocyte | Devillers et al. 1994 | hip 52, other implant 22 | 116 | 97 | 89 | Operative and clinical (1 year) |
| 99mTc-leukocyte/ bone | Moragas et al. 1990 | hip 25, knee 5 | 50 | 100 | 91 | Operative and clinical (not specified) |
| 99mTc-antigranulocyte antibody fragment | Ryan 2002 | hip 3, knee 23, other | 55 | 85 | 77 | Operative and clinical (6 months) |
| 99mTc-ciprofloxacin | Sonmezoglu et al. 2001 | hip 11, knee 11, femur 1 | 51 | 92 | 91 | Operative and clinical (3 months) |