| The association between atopic disorders and depression: The Northern Finland 1966 Birth Cohort Study | ||
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In the original publication III, it was investigated whether the strength of the association between atopic disorders and depression was dependent on the severity of the depression. The results (Table 3) showed that the probability of depression – defined by self-reported doctor-diagnosed lifetime depression and with the help of the HSCL-25 depression subscale – increased in line with the increased severity of depressive symptoms in atopic but not in non-atopic females ranging from 3.0 to 4.7-fold (III: Table 2). Among males a corresponding statistically significant association was seen only in the highest depression scores (mean HSCL-25 score over 2.0), adjusted OR being even 6.3-fold (Table 3; III: Table 2).
Table 3. The associations between self-reported doctor-diagnosed lifetime depression and atopic symptoms, verified by skin prick tests as assessed with three logistic regression models according to different cut-off points for HCSL-25 depression subscale (13-items) scores after adjusting for confounding variables* in the Northern Finland 1966 Birth Cohort by gender (III: Table 2).
| The status of atopy | 1.55–4.00 (vs. No depression**) | 1.75–4.00 (vs. No depression**) | 2.01–4.00 (vs. No depression**) |
|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Males | |||
| Allergic symptoms+&Prick+ | 1.6 (0.8–3.3) | 2.1 (1.0–4.8) | 6.3 (1.7–22.2) |
| Allergic symptoms+&Prick- | 0.9 (0.4–2.1) | 1.3 (0.5–3.1) | 3.4 (0.8–14.2) |
| Allergic symptoms-&Prick+ | 0.5 (0.1–2.2) | 0.7 (0.2–3.3) | 3.0 (0.5–18.3) |
| Allergic symptoms-&Prick- | Reference | Reference | Reference |
| Females | |||
| Allergic symptoms+&Prick+ | 3.0 (1.5–6.2) | 3.7 (1.7–8.3) | 4.7 (1.8–12.5) |
| Allergic symptoms+&Prick- | 2.1 (1.1–4.2) | 2.4 (1.1–5.2) | 2.1 (0.8–5.8) |
| Allergic symptoms-&Prick+ | 1.2 (0.3–4.7) | 1.2 (0.2–5.8) | 2.1 (0.4–11.6) |
| Allergic symptoms-&Prick- | Reference | Reference | Reference |
| *Adjusting variables were father’s social class (I and II = highest, III, IV = lowest, V = farmers), mother’s parity (1, 2–3, 4–5, 6 or more), and place of residence in 1966 (rural, urban). ** "No depression" means that subject"s HSCL-25 depression subscale score was equal to 1.0 and he/she had no self-reported doctor-diagnosed lifetime depression. | |||