The patients did not complain any particular symptoms referring to ANS dysfunction. In the clinical examination, signs of autonomic disturbances could not be found. The clinical cardiorespiratory findings, including baseline BP and neurological examinations, were normal in all patients. None of the patients had severe cardiac arrythmias in the ECG recordings. The patients were not under- or overweight. The basic laboratory screening and serum drug levels were within usually recommended ranges in all patients.