Abbreviations

Ab

antibody

cAMP

cyclic adenosine monophosphate

CK/ K

cytokeratin

CSK buffer

cytoskeletal extraction buffer

kDa

kilodalton

EGF

epidermal growth factor

ERK/ p44/42MAPK

extracellular regulated kinase

FTI

farnesyl transferase inhibitor

GAP

GTPase-activating protein

GDP

guanosine 5‘-diphosphate

GEF

guanine nucleotide exchange factor

GRD

GAP-related domain

GTP

guanosine 5‘-triphosphate

LOH

loss of hetorozygosity

MAPK

mitogen-activated protein kinase

MEK

mitogen-activated kinase, ERK kinase

MPNST

malignant peripheral nerve sheath tumor

mRNA

messenger RNA

NF1

type 1 neurofibromatosis

PDGF

platelet-derived growth factor

PI3-kinase

phosphatidylinositol 3-kinase

PKA

protein kinase A

PLC

phospholipase C

RalGDS

Ras-related guanine nucleotide dissociation stimulator

TEWL

transepidermal water loss

PKC

protein kinase C

TGFα

transforming growth factor α

TGFβ

transforming growth factor β

TNFα

tumor necrosis factor α