References

Aarnisalo P, Palvimo JJ & Jänne OA (1998) CREB-binding protein in androgen receptor-mediated signaling. Proc Natl Acad Sci USA 95: 2122-2127.

Alaiya AA, Oppermann M, Langridge J, Roblick U, Egevad L, Brindstedt S, Hellstrom M, Linder S, Bergman T, Jornvall H & Auer G (2001) Identification of proteins in human prostate tumor material by two-dimensional gel electrophoresis and mass spectrometry. Cell Mol Life Sci 58: 307-311.

Andrews PE, Young CY, Montgomery BT & Tindall DJ (1992) Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line. Cancer Res 52: 1525-1529.

Aumüller G & Seitz J (1985) Cytochemistry and biochemistry of acid phosphatases. VI: Immunoelectron microscopic studies on human prostatic and leukocytic acid phosphatases. Prostate 7: 161-169.

Aumüller G, Seitz J, Lilja H, Abrahamsson PA, von der Kammer H & Scheit KH (1990) Species- and organ-specificity of secretory proteins derived from human prostate and seminal vesicles. Prostate 17: 31-40.

Apostol I, Kuciel R, Wasylewska E & Ostrowski WS (1985) Phosphotyrosine as a substrate of acid and alkaline phosphatases. Acta Biochem Pol 32: 187-197.

Banas B, Blaschke D, Fittle F and Hörz W (1994) Analysis of the promoter of the human prostatic acid phosphatase gene. Biochim Biophys Acta 1217: 188-194.

Barettino D, Vivanco Ruiz MM & Stunnenberg HG (1994) Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J 13: 3039-3049.

Barford D (1996) Molecular mechanisms of the protein serine/threonine phosphatases. Trends Biochem Sci 21:407-412.

Beato M (1989) Gene regulation by steroid hormones. Cell 56: 335-344.

Beato M, Herrlich P & Schütz G (1995) Steroid hormone receptors: Many actors in search of a plot. Cell 83: 851-857.

Berg JM (1989) DNA binding specificity of steroid receptors. Cell 57: 1165-1168.

Berrevoets CA, Doesburg P, Steketee K, Trapman J & Brinkmann AO (1998) Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2). Mol Endocrinol 12: 1172-1183.

Bevan CL, Hoare S, Claessens F, Heery DM & Parker MG (1999) The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol Cell Biol 19: 8383-8392.

Bhatia-Gaur R, Donjacour AA, Sciavolino PJ, Kim M, Desai N, Young P, Norton CR, Gridley T, Cardiff RD, Cunha GR, Abate-Shen C & Shen MM (1999) Roles for Nkx3.1 in prostate development and cancer. Genes Dev 13: 966-977.

Blackburn RV, Galoforo SS, Corry PM Lee YJ (1999) Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity. Int J Cancer 82: 293-297.

Blok LJ, de Ruiter PE & Brinkmann AO (1996) Androgen receptor phosphorylation. Endocr Res 22: 197-219.

Bodansky O (1972) Acid phosphatase. Adv Clin Chem 15: 43-147.

Boissonneault M, Chapdelaine A & Chevalier S (1995) The enhancement by pervanadate of tyrosine phosphorylation on prostatic proteins occurs through the inhibition of membrane-associated tyrosine phosphatase. Mol Cell Biochem 153: 139-144.

Bowen C, Bubendorf L, Voeller HJ, Slack R, Willi N, Sauter G, Gasser TC, Koivisto P, Lack EE, Kononen J, Kallioniemi OP & Gelmann EP (2000) Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression. Cancer Res 60: 6111-6115.

Brinkmann AO, Faber PW, van Rooij HC, Kuiper GG, Ris C, Klaassen P, van der korput JA, Voorhorst MM, van laar JH & Mulder E (1989) The human androgen receptor: domain structure, genomic organization and regulation of expression. J Steroid Biochem 34: 307-310.

Brolin J, Skoog L & Ekman P (1992) Immunohistochemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue. Prostate 20: 281-295.

Brookes DE, Zandvliet D, Watt F, Russell PJ & Molloy PL (1998) Relative activity and specificity of promoters from prostate-expressed genes. Prostate 35: 18-26.

Burnstein KL & Cidlowski JA (1993) Multiple Mechanisms for regulation of steroid hormone action. J Cell Biochem 51: 130-134.

Carpino A, Sisci D, Aquila S, Beraldi E, Sessa M, Siciliano L, de Luca G & Andò S (1994) Effects of short-term high-dose testosterone propionate administration on medium molecular-weight proteins of human seminal plasma. Andrologia 26: 241-245.

Celis L, Claessens F, Peeters B, Heyns W, Verhoeven G & Rombauts W (1993) Proteins interacting with an androgen-responsive unit in the C3(1) gene intron. Mol Cell Endocrinol 94: 165-172.

Chamberlain NL, Whitacre DC Miesfeld RL (1996) Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain. J Biol Chem 271: 26772-26778.

Chang C, Kokontis J & Liao ST (1988) Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science 240: 324-326.

Chang C, Saltzman A, Yeh S, Young W, Keller E, Lee HJ, Wang C, Mizokami A. (1995) Androgen receptor: an overview. Crit Rev Eukaryot Gene Expr 5: 97-125.

Chen H, Lin RJ, Schiltz RL, ChakraVarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y & Evans RM (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90: 569-580.

Chen H, Nandi AK, Li X & Bieberich CJ (2002) NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. Cancer Res 62: 338-340.

Chernoff J, Shievella AR, Jost CA, Erikson RL & Neel BG (1990) Cloning of a cDNA for a major human protein-tyrosine-phosphatase. Proc Natl Acad Sci USA 87: 2735-2739.

Chernoff J (1999) Protein tyrosine phosphatases as negative regulators of mitogenic signaling. J Cell Physiol 180: 173-181.

Chevalier S, Landry D & Chapdelaine A (1988) Phosphotyrosine activity of human and canine acid phosphatase of prostatic origin. Prostate 12: 209-219.

Choe BK, Pontes EJ, Dong MK & Rose NR (1980) Double-antibody immunoassay for human prostatic acid phosphatase. Clin Chem 26: 1854-1859.Choe BK, Pontes EJ, Rose NR & Henderson MD (1978) Expression of human prostatic acid phosphatase in a pancreatic islet cell carcinoma. Invest Urol 15: 312-318.

Choe BK, Lillehoj HS, Dong MK, Gleason S, Barron M & Rose NR (1982) Characterization of antigenic sites of human prostatic acid phosphatase. Ann N Y Acad Sci 390: 16-26.

Chu TM, Wang MC, Merrin C, Valenzuela L & Murphy GP (1978) Isoenzymes of human prostatic acid phosphatase. Oncology 35: 198-200.

Chu TM, Wang MC, Lee CL, Killian CS, Valenzuela LA, Wajsman Z, Slack N & Murphy GP (1979) Enzyme markers for prostate cancer. Cancer Detect Prev 2: 693-706.

Claessens F, Celis L, Peeter B, Heyns W, Verhoeven G & Rambauts W (1989) Functional characterization of an androgen response element in the first intron of the C3(1) gene of prostatic binding protein. Biochem Biophys Res Comm 164: 833-840.

Claessens F, Rushmere NK, Davies P, Celis L, Peeters B & Rombauts WA (1990) Sequence-specific binding of androgen-receptor complexes to prostatic binding protein genes. Mol Cell Endocrinol 74: 203-212.

Claessens F, Alen P, Devos A, Peeters B, Verhoeven G & Rombauts W (1996) The androgen-specific probasin response element 2 interacts differentially with androgen and glucocorticoid receptors. J Biol Chem 271: 19013-19016.

Claessens F, Verrijdt G, Schoenmakers E, Haelens A, Peeters B, Verhoeven G & Rombauts W (2001) Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation. J Steroid Biochem Mol Biol 76: 23-30.

Cleutjens CB, Steketee K, van Eekelen CC, van de korput JA, Brinkmann AO & Trapman J (1997) Both androgen receptor and glucocorticoid receptor are able to induce prostate-specific antigen expression, but differ in their growth-stimulating properties of LNCaP cells. Endocrinology 138: 5293-5300.

Cleutjens KB, van Eekelen CC, van der Korput HA, Brinkmann AO & Trapman J (1996) Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J Biol Chem 271: 6379-6388.

Cleutjens KB, van der Korput HA, van Eekelen CC, van Rooij HC, Faber PW & Trapman J (1997a) An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol Endocrinol 11: 148-161.

Cleutjens KB, van der Korput HA, Ehren-van Eekelen CC, Sikes RA, Fasciana C, Chung LW & Trapman J (1997b) A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans. Mol Endocrinol 11: 1256-1265.

Coffey DS & Pienta KJ (1987) New concepts of studying the control of normal and cancer growth of the prostate. In: Coffey DS, Bruchovsky N, Gardner WA, Resnick MI & Karr JP (eds) Current concepts and approaches to the study of prostate cancer, Alan R Liss, Inc. New York, p. 1-73.

Cohen P (1989) The structure and regulation of protein phosphatases. Annu Rev Biochem 58:453-508.

Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC & Rosenfeld RG (1992) Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab 75: 1046-1053.

Cohen P, Peehl DM & Rosenfeld RG (1994) The IGF axis in the prostate. Horm Metab Res 26: 81-84.

Culig Z, Hobisch A, Cronauer MV, RadmayR C, Trapman J, Hittmair A, Bartsch G & Klocker H (1994) Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 54:5474-5478.

Dahlman-Wright K, Wright A, Gustafsson JÅ & Carlstedt-Duke J (1991) Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimmer is mediated by a short segment of five amino acids. J Biol Chem 266: 3107-3122.

Darne C, Morel L, Claessens F, Manin M, Fabre S, Veyssière G, Rambauts W & Jean C (1997) Ubiquitous transcription factors NF1 and Sp1 are involved in the androgen activation of the mouse vas deferens protein promoter. Mol Cell Endocrinol 132: 13-23.

Davidson RE (1990) Structural aspects of human prostatic acid phosphatase and fast atom bombardment mass spectrometric analysis of E.coli L-threonine deaminase. Ph. D. thesis, Purdue University, West Lafayette, IN.

Davis LG, Dibner MD & Battey JF (1986) Basic methods in molecular biology. New York, Elsevier.

Derechin M, Ostrowski W, Galka M & Barnard EA (1971) Acid phosphomonoesterase of human prostate: molecular weight, dissociation and chemical composition. Biochim Biophys Acta 250: 143-154.

Devos A, Claessens F, Alen P, Winderickx J, Heyns, W, Rombauts W & Peeters B (1997) Identification of a functional androgen-response element in the exon 1-coding sequence of the cystatin-related protein gene crp2. Mol Endocrinol 11: 1033-1043.

Dignam JD, Lebovitz RM & Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11: 1475-1489.

Dixon JE (1996) Protein tyrosine phosphatases: their roles in signal transduction. Recent Prog Horm Res 51: 405-414;

Dodd JG, Sheppard PC & Matusik RJ (1983) Characterization and cloning of rat dorsal prostate mRNAs. Androgen regulation of two closely related abundant mRNAs. J Biol Chem 258: 10731-10737.

Dondero F, Pozza D, Mazzilli F & Isidori A (1976) Response of adnexal glands to testosterone stimulation in the mormal adult male. Fertil Steril 27: 806-811.

Drenckhahn D, Waheed A & van Etten R (1987) Demonstration of prostatic-type acid phosphatase in non-lysosomal granules in the crypt epithelium of the human duodenum. Histochemistry 88: 47.52.

Dulinska J, Laidler P, Ostrowski WS, Mrozicki S & Galka M (1997) The effect of dihydrotestosterone on transcription of prostatic acid phosphatase mRNA in human hyperplastic gland. Acta Biochim Pol 44: 751-758.

Durand B, Saunder M, Gaudon C, Roy B, Losson R & Chambon P (1994) Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J 13: 5370-5382.

Dziembor-Gryszkiewicz E, Fikus M, Kazimierczuk Z & Ostrowski W (1978) Activity of human prostatic acid phosphatase toward purine 5"-phosphonucleosides. Bull Acad Pol Sci Biol 26: 815-821.

Eastham JA, Hall SJ, Sehgal I, Wang J, Timme TL, Yang G, Connell-Crowley L, Elledge SJ, Zhang WW & Harper JW (1995) In vivo gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res 55: 5151-5155.

Eastham JA, Chen SH, Sehgal I, Yang G, Timme TL, Hall SJ, Woo SL & Thompson TC (1996) Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models. Hum Gene Ther 7: 515-523.

Eastman A (1987) An improvement to the novel rapid assay for chorlamphenicol acetyltransferase gene expression. Biotechniques 5: 731.

Elo JP, Kvist L, Leinonen K, Isoma V, Henttu P, Lukkarinen O & Vihko P (1995) Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol. J Clin Endocrinol Metab 80: 3494-3500.

Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240: 889-895.

Fabre S, Manin M, Pailhoux E, Veyssiere G & Jean C (1994) Identification of a functional androgen response element in the promoter of the gene for the androgen-regulated aldose reductase-like protein specific to the mouse vas deferens. J Biol Chem 269: 5857-5864.

Farmer G, Connolly ES, Mocco J & Freedman LP (2001) Molecular analysis of the prostate-specific antigen upstream gene enhancer. Prostate 46: 76-85.

Foti AG, Herschman H & Cooper JF (1977) Comparison of human prostatic acid phosphatase by measurement of enzymatic activity and by radioimmunoassay. Clin Chem 23: 95-99.

Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A & Chang C (1999) Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. J Biol Chem 274: 8316-8321.

Fujimoto N, Mizokami A, Harada S & Matsumoto T (2001) Different expression of androgen receptor coactivators in human prostate. Urology 58: 289-294.

Freedman LP (1992) Anatomy of the steroid receptor zinc finger region. Endocr Rev 13: 129-145.

Freedman LP & Luisi BF (1993) On the mechanism of DNA binding by nuclear hormone receptors: a structural and functional perspective. J Cell Biochem 51: 140-150.

Fronsdal K, Engedal N, Slagsvold T & Saatcioglu F (1998) CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1. J Biol Chem 273: 31853-31859.

Funder JW (1993) Mineralocorticoids, glucocorticoids, receptors and pesronse elements. Science 259: 1132-1133.

Garcia-Arenas R, Lin FF, Lin D, Jin LP, Shih CC, Chang C & Lin MF (1995) The expression of prostatic acid phosphatase is transcriptionally regulated in human prostate carcinoma cells. Mol Cell Endocrinol 111: 29-37.

Ghadessy FJ, Lim J, Abdullah AA, Panet-Raymond V, Choo CK, Lumbroso R, Tut TG, Gottlieb B, Pinsky L, Trifiro MA & Yong EL (1999) Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions. J Clin Invest 103: 1517-1525.

Giri D, Ozen M & Ittmann M (2001) Interleukin-6 is an autocrine growth factor in human prostate cancer. Am J Pathol 159: 2159-2165.

Glass CK (1994) Differential recognition of target genes by nuclear receptor monomers, dimmers and heterodimers. Endocr Rev 15: 391-407.

Glass CK, Rose DW & Rosenfold MG (1997) Nuclear receptor coactivators. Curr Opin Cell Biol 9: 222-232.

Gotoh A, Kao C, Ko SC, Hamada K, Liu TJ & Chung LW (1997) Cytotoxic effects of recombinant adenovirus p53 and cell cycle regulator genes (p21 WAF1/CIP1 and p16CDKN4) in human prostate cancers. J Urol 158: 636-641.

Gotoh A, Ko SC, Shirakawa T, Cheon J, Kao C, Miyamoto T, Gardner TA, Ho LJ, Cleutjens CB, Trapman J, Graham FL & Chung LW (1998) Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer. J Urol 160: 220-229.

Grayhack JT, Keeler TC & Kozlowski JM (1987) Carcinoma of the prostate. Cancer 60: 589-601.

Greenberg NM, DeMayo FJ, Sheppard PC, Barrios R, Lebovitz R, Finegold M, Angelopoulou R, Dodd JG, Duckworth ML, Rosen JM & Matusik RJ (1994) The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice. Mol Endocrinol 8: 230-239.

Greenberg NM, DeMayo F, Finegold MJ, Medina D, Tilley WD, Aspinall JO, Cunha GR, Donjacour AA, Matusik RJ & Rosen JM (1995) Prostate cancer in a transgenic mouse. Proc Natl Acad Sci USA 92: 3439-3443.

Griffiths JC (1980) Prostate-specific acid phosphatase: re-evaluation of radioimmunoassay in diagnosing prostatic disease. Clin Chem 26: 433-436.

Gronemeyer H & Laudet V (1995) Transcription factors 3: nuclear receptors. Protein Profile 2: 1173-1308.

Guan K, Haun RS, Watson SJ, Geahlen RL & Dixon JE (1990) Cloning and expression of protein-tyrosine-phosphatase. Proc Natl Acad Sci USA 87: 1501-1505.

Gutman AB & Gutman EN (1938) An acid phosphatase occurring in the serum of patients with metastasizing carcinoma of prostate gland. J Clin Invest 17: 473-478.

Gyorkey F (1973) Some aspects of cancer of the prostate gland. Methods Cancer Res 10: 279-368.

Hakalahti L, Vihko P, Henttu P, Autio-Harmainen H, Soini Y & Vihko R (1993) Evaluation of PAP and PSA gene expression in prostatic hyperplasia and prostatic carcinoma using Northern blot analysis, in situ hybridization and immunochemical stainings with monoclonal and bispecific antibodies. Int J Cancer 55: 590-597.

Haelans A, Verrijdt G, Schoenmakers E, Alen P, Peeters B, Rombauts W, Claessens F (1999) The first exon of the human sc gene contains an androgen responsive unit and an interferon regulatory factor element. Mol Cell Endocrinol 153: 91-102.

He B, Kemppainen JA, Voegel JJ, Gronemeyer H & Wilson EM (1999) Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain. J Biol Chem 274: 37219-37225.

He B, Kenppainen JA & Wilson EM (2000) FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor. J Biol Chem 275: 22986-22994.

He B, Bowen NT, Minges JT & Wilson EM (2001) Androgen-induced NH2- and COOH-terminal Interaction Inhibits p160 coactivator recruitment by activation function 2. J Biol Chem 276: 42293-42301.

He B, Minges JT, Lee LW & Wilson EM (2002) The FXXLF Motif Mediates Androgen Receptor-specific Interactions with Coregulators. J Biol Chem 277: 10226-10235.

He WW, Sciavolino PJ, Wing, Augustus M, Hudson P, Meissner PS, Curtis RT, Shell BK, Bostwick DG, Tindall DJ, Gelmann EP, Abate-Shen C & Carter KC (1997) A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. Genomics 43: 69-77.

Heinlein CA & Chang C (2002) Androgen Receptor (AR) Coregulators: An Overview. Endocr Rev 23: 175-200.

Hellberg CB, Burden-Gulley SM, Pietz GE & Brady-Kalnay SM (2002) Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells. J Biol Chem 277: 11165-11173.

Heller JE (1987) Prostatic acid phosphatase: its current clinical status. J Urol 137: 1091-1103.

Henttu P, Liao S & Vihko P (1992) Androgens up-regulate the human prostate-specific antigen mRNA but down-regulate the prostatic acid phosphatase mRNA in the LNCaP cell line. Endocrinology 130: 766-772.

Henttu P & Vihko P (1993) Growth factor regulation of gene expression in the human prostatic carcinoma cell line LNCaP. Cancer Res 53: 1051-1058.

Henttu P & Vihko P (1996) Effect of tumor-promoting phorbol ester on androgen regulated gene expression in prostatic LNCaP cells. In vitro biology of sex steroid hormone action, Churchill livingstone, Tokyo, pp. 384-395.

Hibbard MD, McCarthy RC & Markowitz H (1983) Isolation and characterization of electrophoretic variants of human prostatic acid phosphatase. Clin Chem 29: 1886-1889.

Hobisch A, Eder IE, Putz T, Horninger W, Bartsch G, Klocker H & Culig Z (1998) Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. Cancer Res 58: 4640-4645.

Horozewicz J, Leong S, Kawinski E, Karr J, Rosenthal H, Chu T, Mirand E & Murphy G (1983) LNCaP model of human prostatic carcinoma. Cancer Res 43: 1809-1818.

Huang W, Shostak Y, Tarr P, Sawyers C & Carey M (1999) Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer. J Biol Chem 274: 25756-25768.

Hull GW, McCurdy MA, Nasu Y, Bangma CH, Yang G, Shimura S, Lee HM, Wang J, Albani J, Ebara S, Sato T, Timme TL & Thompson TC (2000) Prostate cancer gene therapy: comparison of adenovirus-mediated expression of interleukin 12 with interleukin 12 plus B7-1 for in situ gene therapy and gene-modified, cell-based vaccines. Clin Cancer Res 6: 4101-4109.

Härd T, Kellenbach E, Boelens R, Kaptein R, Dahlman K, Carlstedt-Duke J, Freedman LP, Maler BA, Hyde EI & Gustafsson JA (1990) 1H NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements. Biochemistry 29: 9015-9023.

Höyhtyä M, Vihko P, Vuolas L, Tryggvason K & Vihko R (1987) High-affinity monoclonal antibodies specific for human prostatic acid phosphatase. Clin Chem 33: 103-107.

Ikonen T, Palvimo JJ, Kallio PJ, Moilanen A & Jänne OA (1994) Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation. Endocrinology. 135: 1359-1366.

Ikonen T, Palvimo JJ & Jänne OA (1997) Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators. J Biol Chem 272: 29821-29828.

Jakob CG, Lewinski K, Kuciel R Ostrowski W & Lebioda L (2000) Crystal structure of human prostatic acid phosphatase. Prostate 24: 211-218.

Jenster G, van de Korput HA, Trapman J & Brinkmann AO (1995) Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. J Biol Chem 270: 7341-7346.

Jiménez-Lara AM & Aranda A (1999) Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity. J Biol Chem 274: 13503-13510.

Kamoshida S & Tsutsumi Y (1990) Extraprostatic localization of prostatic acid phosphatase and prostate-specific antigen: distribution in cloacogenic glandular epithelium and sex-dependent expression in human anal gland. Hum Pathol 21: 1108-1111.

Kang HY, Lin HK, Hu YC, Yeh S, Huang KE & Chang C (2001) From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proc Natl Acad Sci USA 98:.3018-3023.

Kasper S, Rennie PS, Bruchovsky N, Sheppard PC, Cheng H, Lin L, Shiu RP, Snoek R & Matusik RJ (1994) Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene. J Biol Chem 269: 31763-31769.

Kasper S, Rennie PS, Bruchovsky N, Lin L, Cheng H, Snoek R, Dahlman-Wright K, Gustafsson JA, Shiu RP, Sheppard PC & Matusik RJ (1999) Selective activation of the probasin androgen-responsive region by steroid hormones. J Mol Endocrinol 22: 313-325.

Keyse SM (1995) An emerging family of dual specificity MAP kinase phosphatases. Biochim Biophys Acta 1265: 152-160.

Kuciel R, Bakalova A, Mazurkiewicz A, Bilska A & Ostrowski W (1990) Is the subunit of prostatic acid phosphatase active? Reversible denaturation of prostatic acid phosphatase. Biochem Int 22: 329-334.

LaCount MW, Handy G & Lebioda L (1998) Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. J Biol Chem 273: 30406-30409.

Lad PM, Cooper JF, Learn DB & Olson CV (1984) Identification of structural and secretory lectin-binding glycoproteins of normal and cancerous human prostate. Biochim Biophys Acta 791: 186-197.

Lam WKW, Yam LT, Wilbur HJ, Taft E &Li CY (1979) Comcarision of acid phosphatase isoenzymes of human seminal fluid, prostate, and leukocytes. Clin Chem 25: 1285-1289.

Lam KW, Li CY, Yam LT, Smith RS & Hacker B (1982) Comparision of prostatic and nonprostatic acid phosphatase. Ann NY Acad Sci 390: 1-15.

Lam KW, Li CY, Yam LT, Sun T, Lee G & Ziesmer S (1989) Improved immnohistochemical detection of prostatic acid phosphatase by a monoclonal antibody. Prostate 15: 13-21.

Lareyre JJ, Claessens F, Rombauts W, Dufaure JP & Drevet JR (1997) Characterization of an androgen response element within the promoter of the epididymis-specific murine glutathione peroxidase 5 gene. Mol Cell Endocrinol 129: 33-46.

Latham JP, Searle PF, Mautner V & James ND (2000) Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector. Cancer Res 60: 334-341.

Lee HJ, Fillers WS & Iyengar MR (1988) Phosphocreatine, an intracellular high-energy compound, is found in the extracellular fluid of the seminal vesicles in mice and rats. Proc Natl Acad Sci USA 85: 7265-7269.

Lee H, Chu TM, Li SSL & Lee C (1991a) Homodimer and heterodimer subunits of human prostate acid phosphatase. Biochem J 277: 759-765.

Lee H, Lee C & Li SSL (1991b) Comparison of the antigenic peptides between human prostatic and lysosomal acid phosphatase. J Prot Chem 10: 253-256.

Li CY, Lam WKW & Yam LT (1980) Immunohistochemical diagnosis of prostatic cancer with metastasis. Cancer 46: 706-712.

Li HC, Chernoff J Chen LB & Kirschonbaum A (1984) A phosphotyrosyl-protein activity associated with acid phosphatase from human prostate gland. Eur J Biochem 138: 45-51.

Lilja H & Abrahamsson PA (1988) Three predominant proteins secreted by the human prostate gland. Prostate 12: 29-38.

Li L & Dixon JE (2000) Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases. Semin Immunol 12: 75-84.

Lim J, Ghadessy FJ, Abdullah AA, Pinsky L, Trifiro M & Yong EL (2000) Human androgen receptor mutation disrupts ternary interactions between ligand, receptor domains, and the coactivator TIF2 (transcription intermediary factor 2). Mol Endocrinol 14: 1187-1197.

Lin MF, Lee C, Li SSL & Chu TM (1983) Purification and characterization of a new human prostatic acid phosphatase isoenzyme. Biochemistry 22: 1055-1062.

Lin MF & Clinton GM (1986) Human prostatic acid phosphatase has phosphotyrosyl-protein phosphatase activity. Biochem J 235: 351-357.

Lin CT, Liu JW, Song XX, Wu JY, Lam KW, Yam LT & Li CY (1986a) Immunoultrastructural demonstration of prostatic acid phosphatase isoenzyme 2 in prostatic carcinoma. J Urol 136:173-180.

Lin MF, Lee CL & Clinton GM (1986b) Tyrosyl kinase activity is inversely related to prostatic acid phosphatase activity in two human prostate carcinoma cell lines. Mol Cell Biol 6: 4753-4757.

Lin MF & Clinton GM (1987) Human prostatic acid phosphatase and its phosphotyrosyl-protein phosphatase activity. Adv Prot Phosphatases 4: 199-228.

Lin MF & Clinton GM (1988) The epidermal growth factor receptor from prostate cells is dephosphorylated by a prostate-specific phosphotyrosyl phosphatase. Mol Cell Biol 8: 5477-5485.

Lin MF, Li SSL Chu TM & Lee C (1990) Comparison of human prostatic acid phosphatase with acid phosphatase isoenzymes from the lung and spleen. J Clin Lab Anal 4: 420-425.

Lin MF, Da Volio J & Garcia-Arenas R (1992) Expression of human prostatic acid phosphatase activity and the growth of prostate carcinoma cells. Cancer Res 52: 4600-4607.

Lin MF, Garcia-Arenas R, Chao YC, Lai M, Patel PC, Xia XZ (1993a) Regulation of prostatic acid phosphatase expression and secretion by androgen in LNCaP human prostate carcinoma cells. Arch Biochem Biophys 300: 384-390.

Lin MF, Garcia-Arenas R, Kawachi M & Lin FF (1993b) Regulation of the expression of prostatuc acid phosphatase in LNCaP human prostate carcinoma cells. Cell Mol Biol Res 39: 739-750.

Lin MF & Garcia-Arenas R (1994) Effect of cell density on androgen regulation of the mRNA level of human prostatic acid phosphatase. Mol Cell Endocrinol 99: 21-24.

Lin MF, Garcia-Arenas R, Xia XZ & Lin FF (1994) The cellular level of prostatic acid phosphatase and the growth of human prostate carcinoma cells. Differentiation 57: 143-149.

Lin MF & Meng TC (1996) Tyrosine phosphorylation of a 185 kDa phosphoprotein (pp185) inversely correlated with the cellular activity of human prostatic acid phosphatase. Biochem Biophys Res Comm 226: 206-213.

Lin MF, Meng TC, Rao PS Chang C, Schönthal AH & Lin FF (1998) Expression of human prostatic acid phosphatase correlates with androgen-stimulated cell proliferation in prostate cancer cell lines. J Biol Chem 273: 5939-5947.

Lin MF, Lee MS, Garcia-Arenas R & Lin FF (2000) Differential responsiveness of prostatic acid phosphatase and prostate-specific antigen mRNA to androgen in prostate cancer cells. Cell Biol Int 24: 681-689.

Lin MF, Lee MS, Zhou XW, Andressen JC, Meng TC, Johansson SL, West WW, Taylor RJ, Anderson, JR & Lin, FF (2001) Decreased expression of cellular prostatic acid phosphatase increases tumorigenicity of human prostate cancer cells. J Urol 166: 1943-1950.

Lindqvist Y, Schneider G & Vihko P (1993) Three-dimensional structure of rat acid phosphatase in complex with L(+)-tartrate. J Biol Chem 268: 20744-20746.

Lindqvist Y, Schneider G & Vihko P (1994) Crystal structures of rat acid phosphatase complexed with the transition state analogs vanadate and molybdate: implications for the reaction mechanism. Eur J Biochem 221: 139-142.

Loor R, Wang MC, Valenzuela L & Chu TM (1981) Expression of prostatic acid phosphatase in human prostate cancer. Cancer Lett 14: 63-69.

Loreni F, Stavenhagen J, Kalff M & Robins DM (1988) A complex androgen-response enhancer resides 2 kilobases upstream of the mouse slp gene. Mol Cell Biol 8: 2350-2360.

Lovelace L, Lewinski K, Jakob CG Kuciel R, Ostrowski W & Lebioda L (1997) Prostatic acid phosphatase: structural aspects of inhibition by L-(+)-tartrate ions. Acta Biochim Pol 44: 673-678.

Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS & Wilcon EM (1988a) Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 240: 327-330.

Lubahn DB, Joseph DR, Sar M, Tan J, Higgs HN, Larson RE, French FS & Wilson EM (1988b) The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Mol Endocrinol 2: 1265-1275.

Luchter-Wasyl E & Ostrowski W (1974) Subunit stucture of human prostatic acid phosphatase. Biochim Biophys Acta 365: 349-359.

Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR & Sigler PB (1991) Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352: 497-505.

Mack DO, Reed VL & Smith LD (1987) Native blot and immunotransfer of human prostatic acid phosphatase isoenzymes. Anal Biochem 167: 53-61.

Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M & Chambon P (1995) The nuclear receptor superfamily: the second decade. Cell 83: 835-839.

Martiniello-Wilks R, Garcia-Aragon J, Daja MM, Russell P, Both GW, Molloy PL, Lockett LJ & Russell PJ (1998) In vivo gene therapy for prostate cancer: preclinical evaluation of two different enzyme-directed prodrug therapy systems delivered by identical adenovirus vectors. Hum Gene Ther 9: 1617-1626.

Matias PM, Donner P, Coelho R, Thomaz M, Peixoto C, Macedo S, Otto N, Jeschko S, Scholz P, Wegg A, Bäsler S, Schäfer M, Egner U & Carrondo MA (2000) Structural evidence for ligand specificity in the binding domain of the human androgen receptor. J Biol Chem 275: 26164-26171.

McKenna NJ, Wu J, Nawaz Z, Tsai SY, Tsai MJ & O’Malley BW (1999) Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions. J Steroid Biochem Mol Biol 69: 3-12.

Mctigue JJ & van Etten RL (1978a) An essential active-site histidine residue in human prostatic acid phosphatase. Ethoxyformlation by diethyl pyrocarbonate and phosphorylation by a substrate. Biochem Biophys Acta 523: 407-421.

Mctigue JJ & van Etten RL (1978b) An essential arginine residue in human prostatic acid phosphatase. Biochim Biophys Acta 523: 422-429.

Mctigue JJ & van Etten RL (1982) Isolation, Characterization, and spontaneous interconvention of two forms of human prostatic acid phosphatase. Prostate 3: 165-181.

Meng TC & Lin MF (1998) Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. J Biol Chem 273: 22096-22104.

Meng TC, Lee MS & Lin MF (2000) Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells. Oncogene 19: 2664-2677.

Monget P, Pisselet C & Monniaux D (1998) Expression of insulin-like growth factor binding protein-5 by ovine granulosa cells is regulated by cell density and programmed cell death in vitro. J Cell Physiol 177: 13-25.

Moras D & Gronemeye H (1998) The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol 10: 384-391.

Mori K & Wakasugi C (1985) Immunocytochemical demonstration of prostatic acid phosphatase: different secretion kinetics between normal, hyperplastic and neoplastic prostate. J Urol 133: 877-883.

Morris MF, Waheed A, Risley JM & Van Etten RL (1989) Carbohydrate removal fails to eliminate the hetergeneity of human prostatic acid phosphatase. Clin Chem Acta 182: 9-20.

Moss DW, Raymond FD & Wile DB (1995) Clinical and biological aspects of acid phosphatase. Crit Rev Clin Lab Sci 32(4):431-467.

Mustonen MV, Isomaa VV, Vaskivuo T, Tapanainen J, Poutanen MH, Stenback F, Vihko RK & Vihko PT (1998) Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle. J Clin Endocrinol Metab 83: 1319-1324.

Mumby MC & Walter G (1993) Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Physiol Rev 1993 73: 673-699.

Nazareth LV & Weigel NL (1996) Activation of the human androgen receptor through a protein kinase A signaling pathway. J Biol Chem 271: 19900-19907.

Neel BG & Tonks NK (1997) protein tyrosine phosphatases in signal transduction. Curr Opin Cell Biol 9: 193-204.

Neumann JR, Morency CA & Russian KO (1987) A novel rapid assay for chloramphenicol acetyltransferase gene expression. Biotechniques 5: 444-447.

Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK & Milburn MV (1998) Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 395: 137-143.

Oesterling JE (1991) Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J Urol 145: 907-923.

Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, Grall F, Dube A, Weiss A, Brown L, Quinn G, Kas K, Endress G, Kunsch C & Libermann TA (2000) PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. J Biol Chem 275: 1216-1225.

Onate AS, Tsai SY, Tsai MJ & O’malley BW (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357.

Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP & O’malley BW (1998) The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. J Biol Chem 273: 12101-12108.

O’Malley BW & Conneely OM (1992) Orphan receptors: in search of a unifying hypothesis for activation. Mol Endocrinol 6: 1359-1361.

Orti E, Bodwell JE & Munck A (1992) Phosphorylation of steroid hormone receptors. Endocr Rev 13: 105-128.

Ostanin K, Saeed A & van Etten RL (1994) Heterologous expression of human prostatic acid phosphatase and site-directed mutagenesis of the enzyme active site. J Biol Chem 269: 8971-8978.

Ostman A, Yang Q & Tonks NK (1994) Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Proc Natl Acad Sci USA 91: 9680-9684.

Ostrowski W, Bhargava AK, Dziembor E, Gizler M, Gryszkiewicz J & Barnard EA (1976) Acid phosphomonoesterase of human prostate. Carbohydrate content and optical properties. Biochim Biophys Acat 453: 262-269.

Ostrowski W (1978) Isolation of -phosphohistidine from a phosphoryl-enzyme intermediate of human prostatic acid phosphatase. Biochim Biophys Acta 526: 147-153.

Palvimo JJ, Reinikainen P, Ikonen T, Kallio PJ, Moilanen A & Jänne OA (1996) Mutual transcriptional interference between RelA and androgen receptor. J Biol Chem 271: 24151-24156.

Pang S, Dannull J, Kaboo R, Xie Y, Tso CL, Michel K, deKernion JB & Belldegrun AS (1997) Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen. Cancer Res 57: 495-499.

Paxton LL, Li LJ, Secor V, Duff JL, Naik SM, Shibagaki N & Caughman SW (1997) Flanking sequences for the human intercellular adhesion molecule-1 NF-kappaB response element are necessary for tumor necrosis factor alpha-induced gene expression. J Biol Chem 272: 15928-15935.

Pentyala SN, Lee J, Hsieh K, Waltzer WC, Trocchia A, Musacchia L, Rebecchi MJ & Lidereau R (2000) Prostate cancer: a comprehensive review. Med Oncol 17: 85-105.

Peters C, Geier C, Pohlmann R, Waheed A, Von Figura K, Roiko K, Virkkunen P, Henttu P & Vihko P (1989) High degree of homology between primary structure of human lysosomal acid phosphatase and human prostatic acid phosphatase. Biol Chem Hoppe-Seyler 370: 177-181.

Pfeiffer D, Kimmig R, Herrmann J, Ruge M, Fisseler-Eckhoff A, Scheidel P, Jensen A, Schatz H & Pfeiffer A (1998) Epidermal-growth-factor receptor correlates negatively with cell density in cervical squamous epithelium and is down-regulated in cancers of the human uterus. Int J Cancer 79: 49-55.

Pohlmann R, Krentler C, Schmidt B, Schröder W, Lorkowski G, Cully J, Mersmann G, Geier C, Waheed A, Gottschalk S, Grzeschik K, Hasilik A & von Figura K (1988) Human lysosomal acid phosphatase: Cloning, expression and chromosomal assignment. EMBO J 7: 2343-2350.

Porvari K, Herrala A, Kurkela R, Taavistsainen P, Lindqvist Y, Schneider G & Vihko P (1994) Site-directed mutagenesis of prostatic acid phosphatase: catalytically important aspartic acid 258, substrate specificity and oligomerization. J Biol Chem 269: 22642-22646.

Porvari K (1995) Rat prostatic acid phosphatase: structural characterization of the enzyme and androgen regulation of the transcripts. Ph. D. thesie, D 356, Oulu University, Oulu, Finland.

Porvari K, Kurkela R, Kivinen A & Vihko P (1995) Differential androgen regulation of rat prostatic acid phosphatase transcripts. Biochem Biophys Res Commun 213: 861-868.

Prescott JL, Blok L & Tindall DJ (1998) Isolation and androgen regulation of the human homeobox cDNA, NKX3.1. Prostate 35: 71-80.

Reid KJ, Hendy SC, Saito J, Sorensen P & Nelson CC (2001) Two classes of androgen receptor elements mediate cooperativity through allosteric interactions. J Biol Chem 276: 2943-2952.

Reif AE, Schlesinger RM, Fish CA & Robinson CM (1973) Acid phosphatase isoenzyme in cancer of the prostate. Cancer 31: 689-699.

Reinikainen P, Palvimo JJ & Jänne OA (1996) Effects of mitogens on androgen receptor-mediated transactivation. Endocrinology 137: 4351-4357.

Rennie PS, Bruchovsky N, Leco KJ, Sheppard PC, McQueen SA, Cheng H, Snoek R, Hamel A, Bock ME, MacDonald BS, Nickel BE, Chang C, Liao S, Cattini P & Matusik RJ, (1993) Characterisation of two cis-acting DNA elements involved in the androgen regulation of the probasin gene. Mol Endocrinol 7: 23-36.

Riegman PH, Vlietstra RJ, van de korput JA, Brinkmann AO & Trapman J (1991) The promoter of the prostate-specific antigen gene contains a functional androgen responsive element. Mol Endocrinol 5: 1921-1930.

Risley MJ & van Etten RL (1987) Structures of the carbohydrate moieties of human prostatic acid phosphatase elucidated by 1H nuclear magnetic resonance spectroscopy. Arch Biochem Biophys 258: 404-412.

Roiko K, Jänne OA & Vihko P (1990) Primary structure of rat secretory acid phosphatase and copparison to other phosphatase. Gene 89: 223-229.

Rosenthal N (1987) Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol 125: 704-720.

Roy AK, Tyagi RK, Song CS, Lavrovsky Y, Ahn SC, Oh TS & Chatterjee B (2001) Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction. Ann NY Acad Sci 949: 44-57.

Rönnberg L Vihko P, Sajanti E & Vihko R (1981) Clomiphene citrate administration to normogonadotropic subfertile men: Blood hormone changes and activation of acid phosphatase in seminal fluid. Int J Androl 4: 372-378.

Saini MS & van Etten RL (1979) An essential carboxylic acid group in human prostate acid phosphatase. Biochim Biophys Acta 568: 370-376.

Sack JS, Kish KF, Wang C, Attar RM, Kiefer SE, An Y, Wu GY, Scheffler JE, Salvati ME, Krystek SR, Weinmann R & Einspahr HM (2001) Crystallographic structures of the ligang-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone. Proc Natl Acad Sci USA 98: 4904-4909.

Schneider G Lindqvist Y & Vihko P (1993) Three-dimensional structure of rat acid phosphatase. EMBO J 12: 2609-2615.

Schoenmakers E, Alen P, Verrijdt G, Peeters B, Verhoeven G, Rombauts W & Claessens F (1999) Differential DNA binding by the androgen and glucocorticoid receptors involves the second Zn-finger and a C-terminal extension of the DNA-binding domains. Biochem J 341: 515-521.

Schoenmakers E, Verrijdt G, Peeters B, Verhoeven G, Rombauts W & Claessens F (2000) Differences in DNA binding characteristics of the androgen and glucocorticoid receptors can determine hormone-specific response. J Biol Chem 275: 12290-12297.

Schuur ER, Henderson GA, Kmetec LA, Miller JD, Lamparski HG & Henderson DR (1996) Prostate-specific antigen expression is regulated by an upstream enhancer. J Biol Chem 271: 7043-7051.

Schwabe JW, Neuhaus D & RhoDes D (1990) Solution structure of the DNA binding domainof the oestrogen receptor. Nature 348: 458-461.

Seitz J & Aumüller G (1985) Cytochemistry and biochemistry of acid phosphatases V: Electrophoretic studies on the heterogeneity of acid phosphatases from human prostate, seminal fluid, and leukocytes. Prostate 7: 73-90.

Sharief FS, Lee H, Leuderman MM, Lundwall Å, Deaver LL, Lee C & Li SSL. (1989) Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase. Biochem Biophys Res Comm 160: 79-86.

Sharief FS & Li SSL (1992) Structure of human prostatic acid phosphatase gene. Biochem Biophys Res Comm 184: 1468-1476.

Shaw LM, Yang N, Brook JJ, Neat M, Marsh E & Seamonds B (1981) Immunohistachemical evaluation of the organ specificity of prostatic acid phosphatase. Clin Chem 27: 1505-1512.

Sheldon LA, Smith CL, Bodwell JE, Munck AU & Hager GL (1999) A ligand binding domain mutation in the mouse glucocorticoid receptor functionally links chromatin remodeling and transcription initiation. Mol Cell Biol 19: 8146-8157.

Simons JW, Mikhak B, Chang JF, DeMarzo AM, Carducci MA, Lim M, Weber CE, Baccala AA, Goemann MA, Clift SM, Ando DG, Levitsky HI, Cohen LK, Sanda MG, Mulligan RC, Partin AW, Carter HB, Piantadosi S, Marshall FF & Nelson WG (1999) Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer. Cancer Res 59: 5160-5168.

Sinha AA, Gleason DF, Wilson MJ, Wick MR, Reddy PK & Blackard CE (1988) Relationship of prostatic aicd phosphatase localization in human prostate by a monoclonal antibody with the Gleason grading system. Prostate 13: 1-15.

Singh RK, Llansa N, Bucana CD, Sanchez R, Koura A & Fidler IJ (1996) Cell density-dependent regulation of basic fibroblast growth factor expression in human renal cell carcinoma cells. Cell Growth Differ 7: 397-404.

Slagsvold T, Kraus I, Fronsdal K & Saatcioglu F (2001) DNA binding-independent transcriptional activation by the androgen receptor through triggering of coactivators. J Biol Chem 276: 31030-31036.

Smith JK & Whitby LG (1968) The heterogeneity of prostatic acid phosphatase. Biochim Biophys Acta 151: 607-618.

Solin T, Koutturi M, Pohlmann R & Vihko P (1990) Gene expression and prostate specificity of human prostatic acid phosphatase (PAP): evaluation by RNA blot analysis. Biochim Biophys Acta 1048: 72-77.

Steadman DJ, Giuffrida D & Gelmann EP (2000) DNA-binding sequence of the human prostate-specific homeodomain protein NKX3.1. Nucleic Acids Res 28: 2389-2395.

Steiner MS, Zhang X, Wang Y & Lu Y (2000) Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde. Cancer Res 60: 4419-4425.

Streuli M (1996) Protein tyrosine phosphatases in signaling. Curr Opin Cell Biol 8: 182-188.

Suzuki H, Akakura K, Komiya A, Aida S & Shimazaki J (1996) Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome. Prostate 29: 153-158.

Taga EM, Moore DL & van Etten RL (1983) Studies on the structural basis of the heterogeneity of human prostatic and seminal acid phosphatases. Prostate 4: 141-150.

Taplin ME, Bubley GJ, Ko YJ, Small EJ, Upton M, Rajeshkumar B & Balk SP (1999) Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. Cancer Res 59: 2511-2515.

Taplin ME, Bubley GJ, Shuster TD, Frantz ME, Spooner AE, Ogata GK, Keer HN & Balk SP (1995) Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 332:1393-1398.

Tessier S, Chapdelaine A & Chevalier S (1987) Effect of vanadate on protein phosphorylation and on acid phosphatase activity in the canine prostate. Mol Cell Endocrinol 64: 87-94.

Tilley WD, Marcelli M, Wilson JD & McPhaul MJ (1989) Characterization and expression of a cDNA encoding the human androgen receptor. Proc Natl Acad Sci USA 86: 327-331.

Tonks NK & Neel BG (1996) From form to function: signaling by protein tyrosine phosphatases. Cell. 87:365-368.

Tora L, White J, Brou C, Tasset D, Webster N, Scheer E Chambon P (1989) The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell 59: 477-487.

Trapman J, Klaassen P, Kuiper GG, van der Porput JA, Faber PW, van Rooij HC, Geurzvan van Kessel A, Voorhorst MM, Mulder E & Brinkman AO (1988) Cloning, structure and expression of a cDNA encoding the human androgen receptor. Biochem Biophys Res Commun 153: 241-248.

Truss M & Beato M (1993) Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev 14: 459-479.

Ueda T, Bruchovsky N & Sadar MD (2002) Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J Biol Chem 277: 7076-7085.

Vaarala MH, Porvari KS, Kyllonen AP, Mustonen MV, Lukkarinen O & Vihko PT (1998) Several genes encoding ribosomal proteins are over-expressed in prostate-cancer cell lines: confirmation of L7a and L37 over-expression in prostate-cancer tissue samples. Int J Cancer 78: 27-32.

Vaarala MH, Lukkarinen O, Marttila T, Kyllonen AP, Porvari KS & Vihko PT (2000) Prostatic expression of human 5alpha-reductase type 2 during finasteride therapy: a randomized, double-blind, placebo-controlled study. World J Urol 18: 406-410.

van Etten RL (1982) Human prostatic acid phosphatase: a histidine phosphatase. Ann N Y Acad Sci 390: 27-51.

van Etten RL & Waheed A (1985) Biosynthesis of prostatic acid phosphatase in a normal human cell line. Arch Biochem Biophys 243: 264-273.

van Etten RL, Davidson R, Stevis PE, MacArthur H & Moore DL (1991) Covalent structure, disulfide bonding, and identification reactive surface and active site residues of human prostatic acid phosphatase. J Biol Chem 266: 2313-2319.

van Steenbrugge G, Blankenstein M, Bolt-de Vries J, Romijn J, Schröder F Vihko P (1983) Effect of hormone treatment on prostatic acid phosphatase in a serially transplantable human prostatic adenocarcinoma (PC-82). J Urol 129: 630-633.

van Steenbrugge GJ, van Uffelen CJ, Bolt J & Schroder FH (1991) The human prostatic cancer cell line LNCaP and its derived sublines: an in vitro model for the study of androgen sensitivity. J Steroid Biochem Mol Biol 40: 207-214.

Veldcholte J, Ris-stalpers C, Kuiper GG, Jenster G, Berrevoets C, Claassen E, van Rooij HCJ, Trapman J, Brinkmann AO & Mulder E (1990a) A mutation in the ligand-binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. Biochem Biophys Res Commun 173: 534-540.

Veldcholte J, Voorhost-Ogink MM, Bolt-de Vries J, van Rooij HCJ, Trapman J & Mulder E (1990b) Unusual specificity of the androgen receptor in human prostate tumor cell line LNCaP: high affinity for progestagenic and estrogenic steroids. Biochim Biophys Acta 1052: 187-194.

Verrijdt G, Schoenmakers E, Alen P, Haelens A, Peeters B, Rambauts W & Claessens F (1999) Androgen-specificity of a response unit upstream of the human secretory component gene is mediated by differential receptor binding to an essential androgen response element. Mol Endocrinol 13: 1558-1570.

Vihko P (1978) Characterization of the principal human prostatic acid phosphatase isoenzyme, purified by affinity chromatography and isoelectric focusing. Part II. Clin Chem 24: 1783-1787.

Vihko P, Kontturi M & Korhonen LK (1978) Purification of human prostatic acid phosphatase by affinity chromatography and isoelectric focusing. Part I. Clin Chem 24: 466-470.

Vihko P (1979) Human prostatic acid phosphatase. Purification of a minor enzyme and comparisons of the enzymes. Invest Urol 16: 349-352.

Vihko P, Kostama A, Jänne O, Sajanti E & Vihko R (1980) Rapid radioimmunoassay for prostate-specific acid phosphatase in human serum. Clin Chem 26: 1544-1547.

Vihko P, Lukkarinen O, Kontturi M & Vihko R (1981) Effectiviness of radioimmunoassay to human prostate-specific acid phosphatase in the diagnosis and follow-up of therapy in prostatic carcinoma. Cancer Res 41: 1180-1183.

Vihko P, Kontturi M, Lukkarinen O & Vihko R (1985) Immunoreactive prostatic acid phosphatase in prostatic cancer: diagnosis and follow-up of patients. J Urol 133: 979-982.

Vihko P, Virkkunen P, Henttu P, Roiko K, Solin T & Huhtala ML (1988) Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase. FEBS Lett 236(2): 275-281.

Vihko P, Kurkela R, Porvari K, Herrala A, Lindfors A, Lindqvist Y & Schneider G (1993) Rat acid phosphatase: Overexpression of active secreted enzyme by recombinant baculovirus-infected insect cells, molecular properties and crystallization. Proc Natl Acad Sci USA 90: 799-803.

Vincent JB, Crowder MW & Averill BA (1992) Hydrolysis of phosphate monoesters: a biological problem with multiple chemical solutions. Trends Biochem Sci 17: 105-110.

Virkkunen P, Hedberg P, Palvimo J, Birr E, Porvari K, Ruokonen M, Taavitsainen P, Jänne O & Vihko P (1994) Structure comparison of human and rat prostate-specific acid phosphatase genes and their promoters: idetification of putative androgen response elements. Biochem Biophys Res Comm 202: 49-57.

Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P & Gronemeyer H (1998) The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J 17: 507-519.

vom Bayr E, Harbers M, Um SJ, Benecke A, Chambon P & Losson R (1998) The yeast Ada complex mediates the ligand-dependent activation function AF-2 of retinoid X and estrogen receptors. Genes Dev 12: 1278-1289.

Waheed A, van Etten RL, Gieselmann V & von Figura K (1985) Immunological characterization of human acid phosphatase gene products. Biochem Genetics 23: 309-319.

Wang C, Young WJ & Chang C (2000) Isolation and characterization of the androgen receptor mutants with divergent transcriptional activity in response to hydroxyflutamide. Endocrine 12: 69-76.

Wang Q, Lu JH & Yong EL (2001) Ligand- and coactivator-mediated transactivation function (AF2) of the androgen receptor ligand-binding domain is inhibited by the cognate hinge region. J Biol Chem 276: 7493-7499.

Wasylewska E, Czubak J & Ostrowski WS (1983) Phosphoprotein phosphatase activity of human prostate acid phosphatase. Acta Biochim Pol 30: 175-184.

Wera S & Hemmings BA (1995) Serine/threonine protein phosphatases. Biochem J 31: 17-29.

Winqvist R, Virkkunen P, Grzeschik KH & Vihko P (1989) Chrosomal localization to 3q21→qter and two TaqI RFLPs of the human prostate-specific acid phosphatase gene (ACCP). Cttogenet Cell Genet 52: 68-71.

Wood WM, Dowding JM, Gordon DF & Ridgway EC (1999) An upstream regulator of the glycoprotein hormone alpha-subunit gene mediates pituitary cell type activation and repression by different mechanisms. J Biol Chem 274: 15526-15532.

Woodford-Thomas TA, Rhodes JD & Dixon JE (1992) Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts. J Cell Biol 117: 401-414.

Wu L, Matherly J, Smallwood A, Adams JY, Billick E, Belldegrun A & Carey M (2001) Chimeric PSA enhancers exhibit augmented activity in prostate cancer gene therapy vectors. Gene Ther 8: 1416-1426.

Xie X, Zhao X, Liu Y, Young CY, Tindall DJ, Slawin KM & Spencer DM (2001) Robust prostate-specific expression for targeted gene therapy based on the human kallikrein 2 promoter. Hum Gene Ther 12: 549-561.

Yam LT (1974) Clinical significance of the human prostatic acid phosphatase. Am J Med 56: 604-616.

Yam LT, Janckila AJ, Li CY & Lam WKW (1981) Presence of “prostatic” acid phosphatase in human neutrophils. Invest Urol 19: 34-38.

Yeh S, Miyamoto H, Shima H & Chang C (1998) From estrogen to androgen receptor: A new pathway for sex hormones in prostate. Proc Natl Acad Sci USA 95: 5527-5532.

Yeh S, Chang CH, Miyamoto H, Takatera H, Rahman M, Kang HY, Thin TH, Lin HK & Chang C (1999a) Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators. Keio J Med 48: 87-92.

Yeh S, Lin HK, Kang HY, Thin TH, Lin MF & Chang C (1999) From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proc Natl Acad Sci USA 96: 5458-5463.

Young CY, Montgomery BT, Andrews PE, Qui SD, Bilhartz DL & Tindall DJ (1991) Hormonal regulation of prostate-specific antigen messenger RNA in human prostatic adenocarcinoma cell line LNCaP. Cancer Res 1991 51: 3748-3752.

Yousef GM, Diamandis M, Jung K & Diamandis EP (2001) Molecular cloning of a novel human acid phosphatase gene (ACPT) that is highly expressed in the testis. Genomics 74:385-395.

Zelivianski S, Comeau D & Lin MF (1998) Cloning and analysis of the promoter activity of the human prostatic acid phosphatase gene. Biochem Biophys Res Commun 245:108-112.

Zelivianski S, Larson C, Seberger J, Taylor R & Lin MF (2000) Expression of human prostatic acid phosphatase gene is regulated by upstream negative and positive elements. Biochim Biophys Acta 1491: 123-132.

Zhang J, Thomas TZ, Kasper S & Matusik RJ (2000) A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo. Endocrinology 141: 4698-4710.

Zhang M, Stauffacher CV, Lin D & van Etten RL (1998) Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. J Biol Chem 273: 21714-21720.

Zhang XQ, Lee MS, Zelivianski S & Lin MF (2001) Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem 276: 2544-2550.

Zhang Z, Ostanin K & van Etten RL (1997a) Covalent modification and site-directed mutagenesis of an active site tryptophan oh human prostatic acid phosphatase. Acta Biochim Pol 44: 659-672.

Zhang Z, Zhao Y, Batres Y, Lin MF & Ying SY (1997b) Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP. Biochem Biophys Res Commun 234: 362-365.

Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM & Feldman D (2000) Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med 6: 703-706.

Zheng XM, Wang Y & Pallen CJ (1992) Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature 359: 336-339.

Zhou ZX, Sar M, Simental JA, Lane MV & Wilson EM (1994) A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences. J Biol Chem 269: 13115-13123.