| Regulation of cardiac responses to increased load: Role of endothelin-1, angiotensin II and collagen XV | ||
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The aim of the present study was to characterize the role of autocrine/paracrine factors ET-1 and Ang II in cardiac responses to load in isolated mouse and rat heart, to describe the role of PMCA in cardiac function and to investigate the role of collagen XV in the heart.
Specifically the aims were:
To elucidate the effects of PMCA overexpression on ET-1- and load-induced BNP gene expression responses.
To study the effects of AM on ET-1 induced vasoconstriction.
To characterize the role of endogenous ET-1 and Ang II in Frank-Starling responses of normal and hypertrophied rat hearts.
To establish an isolated, Langendorff-perfused mouse heart model and to characterize the role of ET-1 and Ang II in contractile response to load in mice hearts.
To characterize the role of collagen XV in cardiac function.