| Cytochrome P450 isoform-specific in vitro methods to predict drug metabolism and interactions | ||
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Adsorption, Distribution, Metabolism, Excretion
complementary deoxyribonucleic acid
intrinsic clearance
cytochrome P450
drug-metabolising enzyme
endoplasmic reticulum
flavin-containing monooxygenase type 3
high-performance liquid chromatography
high-throughput screening
concentration of inhibitor in enzymatic reaction
inhibitor concentration decreasing the enzymatic activity by 50% compared to the control reaction
inhibition constant
Michaelis-Menten constant for a substrate
messenger ribonucleic acid
mass spectrometry
nicotine amide diphosphate (reduced form)
new chemical entity, a drug under development
cytochrome P450
polycyclic aromatic hydrocarbon
poor metaboliser
correlation coefficient
concentration of substrate in enzymatic reaction
smooth endoplasmic reticulum
in vitro half life of the compound under study
uridine diphosphate
velocity of metabolite formation in enzymatic reaction
maximal reaction velocity