One of the main obstacles for successful human gene therapy
continues to be the lack of optimal vector systems and, in close
association with this, the lack of ultimate gene delivery methods.
So far, the vectors used are immunogenic, resulting in transient
expression and having deleterious effects on the recipient, or result
in inefficient transduction (Otake et
al. 1998). There is a need to create new, more efficient
and less immunogenic vectors in conjunction with suitable surgical
methods for delivering these vectors to the target tissues.