| Markers of collagen metabolism in the assessment of rheumatoid arthritis.: With special reference to cross-linked carboxyterminal telopeptide of type I collagen (ICTP) | ||
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Osteoclasts contain a tartrate-resistant acid phosphatase that is released into the circulation. The lack of specificity of this enzyme in plasma, its instability in frozen samples, and the presence of enzyme inhibitors in serum limit its clinical usefulness as a bone resorption marker (Cormier 1995).