Chapter 4. Materials and methods

Table of Contents
4.1. Test implants
4.2. In vitro human cell cultures
4.3. Animals
4.4. Surgical procedures
4.5. Specimen processing
4.6. Methods of analysis

4.1. Test implants

Study I: The materials tested were NiTi (54%Ni, 46%Ti, Unitec, U.S.A), stainless steel AISI 316 LVM (12%Ni, 18%Cr, 68%Fe, 2%Mo, Sandvik, Sweden), ASTM Grade 2 commercially pure titanium (TISTO GmbH, Düsseldorf, Germany), white soft paraffin (white soft paraffin is a semi-solid mixture of hydrocarbons obtained from petroleum and bleached) and a composite material known as Silux Plus® (Bisfenol-A-diglyidylmetacrylate 15-20%, triethylglycoldimetacrylate 15-20%, aluminoxide <1%, amorphic siliconoxide 50-60%, 3- metacryloxidepropyltrimetoxisilan <7%, Silux Plus, 3M, USA) Metal test discs of 6x7 mm were taken from a large bar by turning on a lathe. The composite material was prepared using a rubber mould. The surface preparation consisted of electrolytic polishing for stainless steel and water sanding for titanium and NiTi (waterproof silicon carbide paper FEPA P#2400).

Studies II and III: The tested materials were vacuum-melted, drawn and fully annealed NiTi (56 % nickel by weight, 44 % titanium by weight, Af = - 10 ˚C, NiTi Development Co., USA), AO/ASIF stainless steel (Synthes GmbH, Switzerland), and AO/ASIF Ti-6Al-4V alloy (90 % titanium by weight, 6 % aluminium by weight, 4 % vanadium by weight, Synthes GmbH, Switzerland).

Identical round test implants were taken from a longer wire by mechanically cutting. The implants used in both studies were 1.8 mm in diameter and 6 mm in length. The cut ends of the implants were rounded using water-cooled grinding (silicon carbide paper FEPA P#800, Struers, Denmark). The material surfaces were as received: stainless steel was electrolytically polished, NiTi and Ti-6Al-4V were received in a mechanically ground condition.

Study IV: The NiTi and stainless steel materials and surface preparations were as in the studies II and III. Implants of 1.8x18 mm were taken from a longer wire by mechanically cutting, and the cut ends of the implants were rounded as previously.

The test discs and implants were all degreased with 70 % ethanol, washed with an ultrasonic vibrobath and autoclaved (30 min., 121˚C) before the procedures.