Effects of apolipoprotein and low density lipoprotein receptor gene polymorphisms on lipid metabolism, and the lipid risk factors of coronary artery disease
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5.2. Catabolism of LDL

The mean(SD) FCR for autologous LDL was 0.29(0.06) and that for homologous LDL 0.27 (0.05) pools/day. Twelve patients cleared homologous LDL 0.8 to 19.3 % faster than their own, while all the others cleared their own LDL 1.0-21.6% faster than homologous LDL.

The proportion of individuals with the different apo B and apo E genotypes catabolizing homologous LDL faster than their own is shown in Figure 5-1, and the LDL decay curves of the patients with the greatest differences between autologous and homologous LDL are shown in Figure 5-2

Figure 5-1. Numbers of patients catabolising autologous LDL faster than homologous LDL according to the XbaI, EcoRI, Apo E, Ins/del and MspI genotypes.

Figure 5-2. Difference between the catabolic rates of autologous and homologous LDL.

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