| Effects of apolipoprotein and low density lipoprotein receptor gene polymorphisms on lipid metabolism, and the lipid risk factors of coronary artery disease | ||
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The association between coronary artery disease, high Lp(a) values (Frick et al. 1978, Dahlén et al. 1986) and the e 4 allele (Davignon et al. 1988) has been well established. The previously well-known (Brown et al. 1990, Ukkola et al. 1993a) high prevalence of e 4 in the patients with high Lp(a) concentrations in this study suggests that the simultaneous presence of these risk factors confers susceptibility to CAD. The present results also suggest that the combination of a low Lp(a) value and the e 2 allele, both of which are considered antiatherogenic (Nieminen et al. 1992, Sandholzer et al. 1992, Schaefer et al. 1994) does not protect individuals from CAD in the presence of smoking, although the number of patients with the e 2 allele was too small to warrant definite conclusions.
RS-86505-007 had no effect on the Lp(a) concentration, a result that could be expected, since the serum Lp(a) concentration is largely genetically determined by a single gene attributable to differing numbers of kringle 4 repeats (Boerwinkle 1992).