| Effects of apolipoprotein and low density lipoprotein receptor gene polymorphisms on lipid metabolism, and the lipid risk factors of coronary artery disease | ||
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Plasma lipids and the presence of tendon xanthomata in patients with or without the FH-Helsinki mutation detected by the PCR method are shown in Table 5-1. Out of the 37 patients in the FH group, 30 had tendon xanthomata. The FH-Helsinki mutation was present in 25 (23%) of the 110 patients, 23 of whom had clinically confirmed FH.
Table 5-1. Plasma lipids and presence of tendon xanthomata in patients with or without the FH-Helsinki mutation.
| FH patients | Non-FH patients | ||||
|---|---|---|---|---|---|
| FH-Helsinki+ | FH-Helsinki- | FH-Helsinki+ | FH-Helsinki- | ||
| No.of patients | 23 | 14 | 2 | 71 | |
| Xanthomata | 83%(19) | 79%(11) | (0) | (0) | |
| Cholesterol | 10.10±1.59 | 9.44±0.80 | 9.37 | 8.78±0.59 | |
| LDL cholesterol | 8.24±1.45 | 7.47±0.95 | 7.54 | 6.37±0.68 | |
| HDL cholesterol | 1.26±0.30 | 1.33±0.23 | 1.50 | 1.65±0.47 | |
| Triglycerides | 1.35±0.62 | 1.44±0.49 | 0.70 | 1.71±0.76 | |