| Effects of apolipoprotein and low density lipoprotein receptor gene polymorphisms on lipid metabolism, and the lipid risk factors of coronary artery disease | ||
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The purpose of the research was to simplify the diagnosis of familial hypercholesterolemia, to study the role of apolipoprotein B and E polymorphisms in hypercholesterolemia and its treatment, and to compare the lipid risk factors of CAD in men and women. More specifically, the aims were to
develop a PCR method for the diagnosis of the FH-Helsinki mutation
study the metabolism of apolipoprotein B in moderate hypercholesterolemia and the association of its polymorphisms with the plasma lipid and lipoprotein levels
compare the lipid risk factors of angiographically verified CAD in men and women
compare the efficacy of hypocholesterolemic drugs in patients with different apo B and E polymorphisms and the effect of statin and bile-binding resin treatment on CETP activity